Enantioselective, chromatography-free synthesis of β3-amino acids with natural and unnatural side chains

T Gerfaud, YL Chiang, I Kreituss…

文献索引：Gerfaud, Thibaud; Chiang, Ying-Ling; Kreituss, Imants; Russak, Justin A.; Bode, Jeffrey W. Organic Process Research and Development, 2012 , vol. 16, # 4 p. 687 - 696

全文：HTML全文

被引用次数: 9

摘要

β3-Amino acids are key components of some pharmaceuticals, excellent surrogates for metabolically labile α-amino acids, and building blocks for chiral heterocycles. Unfortunately they are not easily accessible in enantiomerically pure form, especially when possessing unnatural side chains. A flexible, chromatography-free process for the synthesis of enantiopure β3-amino acids possessing natural and unnatural side chains is described. ...