Molecular design of artificial ribonucleases using electrostatic interaction

EA Burakova, VN Silnikov

文献索引：Burakova, Ekaterina A.; Silnikov, Vladimir N. Nucleosides, Nucleotides and Nucleic Acids, 2004 , vol. 23, # 6-7 p. 915 - 920

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被引用次数: 10

摘要

A number of small organic ribonucleases have been synthesized with rigid polycationic structures containing an aromatic framework with two residues of bis??quaternary salts of 1, 4?? diazabicyclo [2.2. 2] octane (DABCO) bearing various substituents. The compounds carrying positively charged groups connected via rigid linker are expected to bend the sugar?? phosphate backbone and can stimulate the intramolecular phosphoester transfer reaction.