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… compounds. Part 29: Palladium catalysed arylations and alkynylations of sterically hindered immunomodulatory 2-amino-5-halo-4, 6-(disubstituted) pyrimidines

DR Hannah, EC Sherer, RV Davies, RB Titman…

文献索引:Hannah, Duncan R.; Sherer, Edward C.; Davies, Roy V.; Titman, Roger B.; Laughton, Charles A.; Stevens, Malcolm F. G. Bioorganic and Medicinal Chemistry, 2000 , vol. 8, # 4 p. 739 - 750

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被引用次数: 21

摘要

The immunological agent bropirimine 5 is a tetra-substituted pyrimidine with anticancer and interferon-inducing properties. Synthetic routes to novel 5-aryl analogues of bropirimine have been developed and their potential molecular recognition properties analysed by ...