Improved therapeutic efficacy of doxorubicin through conjugation with a novel peptide drug delivery technology (Vectocell)

F Meyer-Losic, J Quinonero, V Dubois…

文献索引：Meyer-Losic, Florence; Quinonero, Jerome; Dubois, Vincent; Alluis, Bertrand; Dechambre, Mireille; Michel, Matthieu; Cailler, Francoise; Fernandez, Anne-Marie; Trouet, Andre; Kearsey, Jonathan Journal of Medicinal Chemistry, 2006 , vol. 49, # 23 p. 6908 - 6916

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被引用次数: 41

摘要

Improvement in the therapeutic index of doxorubicin, a cytotoxic molecule, has been sought through its chemical conjugation to short (15-23 amino acid) peptide sequences called Vectocell peptides. Vectocell peptides are highly charged drug delivery peptides and display a number of characteristics that make them attractive candidates to minimize many of the limitations observed for a broad range of cytotoxic molecules. The studies reported ...