Synthesis of Aryl and Arylmethyl Phosphonates by Cross??Coupling of Aryl or Arylmethyl Halides (X= I, Br and Cl) with Diisopropyl H??Phosphonate

K Xu, H Hu, F Yang, Y Wu

文献索引：Xu, Kai; Hu, Hao; Yang, Fan; Wu, Yangjie European Journal of Organic Chemistry, 2013 , # 2 p. 319 - 325

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被引用次数: 19

摘要

Abstract An efficient and generally applicable protocol for the palladacycle-catalysed arylation or K 2 CO 3-promoted arylmethylation of diisopropyl H-phosphonate has been developed. The remarkable features of the palladacycle-catalysed arylation reaction include wide substrate scope (aryl iodides, bromides and chlorides), significant shortening of the reaction time (2 or 3 h) and a low catalyst loading of 1 mol-%. Note that with the base K 2 ...