2-(Substituted phenyl) amino analogs of 1-methoxyspirobrassinol methyl ether: Synthesis and anticancer activity

…, R Mezencev, J Mojžiš, M Pilátová, E Balentová…

文献索引：Kutschy, Peter; Salayova, Aneta; Curillova, Zuzana; Kozar, Tibor; Mezencev, Roman; Mojzis, Jan; Pilatova, Martina; Balentova, Eva; Pazdera, Pavel; Sabol, Marian; Zburova, Michaela Bioorganic and Medicinal Chemistry, 2009 , vol. 17, # 10 p. 3698 - 3712

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被引用次数: 29

摘要

New analogs of indole phytoalexin 1-methoxyspirobrassinol methyl ether have been designed by replacement of its 2-methoxy group with 2-(substituted phenyl) amino group. Synthesized by spirocyclization methodology, trans-and cis-diastereoisomers of target compounds were isolated and evaluated as potential anticancer and antimicrobial agents. Their molecular geometries were refined by ab initio minimizations. Pharmacophore ...