Tetrahedron letters

Reactions SRN1 en serie heterocyclique: II. Reactivite du methyl-1 chloromethyl-2 nitro-5 imidazole.

…, JM Surzur, P Vanelle, C Ghiglione, J Maldonado

文献索引：Crozet, Michel P.; Surzur, Jean-Marie; Vanelle, Patrice; Ghiglione, Claude; Maldonado, Jose Tetrahedron Letters, 1985 , vol. 26, # 8 p. 1023 - 1026

全文：HTML全文

被引用次数: 29

摘要

Abstract 1-Methyl-2-chloromethyl-5-nitroimidazole reacts with tertiary nitronate anions in excess to afford in high yields the previously unknown 1-methyl-5-nitro-imidazoles bearing a trisubstituted ethylenic double bond in the 2 position. These compounds are ascribed to a C- alkylation reaction according to the S RN 1 mechanism followed by base-promoted nitrous acid elimination.