Novel Procedure for the Synthesis of 1??Hydroxy??1, 1??bisphosphonic Acids using Phenols as Medium
…, GK Narayanan, R Lenin, M Sivakumaran…
文献索引：Rao, Divvela V. N. Srinivasa; Dandala, Ramesh; Narayanan, Garimella K. A. S. S.; Lenin, Racha; Sivakumaran; Naidu, Andra Synthetic Communications, 2007 , vol. 37, # 24 p. 4359 - 4365
Abstract A facile synthetic route for the synthesis of bisphosphonates in phenols is described. Preparations of some of bisphosphonates, which are presently in clinical use such as risedronic acid and alendronate sodium, are synthesized following this new, simple method. This procedure can be useful for the synthesis of this class of bone??resorptive inhibitors in bulk quantities.
