Synthesis of novel 1??phenyl??1H??indole??2??carboxylic acids. II. Preparation of 3??dialkylamino, 3??alkylthio, 3??alkylsulfinyl, and 3??alkylsulfonyl derivatives
PC Unangst, DT Connor…
文献索引：Unangst, Paul C.; Connor, David T.; Stabler, S. Russell Journal of Heterocyclic Chemistry, 1987 , vol. 24, p. 817 - 820
Abstract The synthesis of novel indole-2-carboxylic acids with amino-and sulfur-containing substituents in the indole 3-position is described. An Ullmann reaction with bromobenzene converted 1H-indoles with 3-(acetylamino)-and 3-(diethylamino)-substituents into 1-phenyl- 1H-indoles. Reaction of 3-unsubstituted indoles with thionyl chloride provided indole 3- sulfinyl chlorides, which reacted with alkyl and aryl Grignard reagents to form the ...
