Synthesis and biological evaluation of 2-trifluoromethyl/sulfonamido-5, 6-diaryl substituted imidazo [2, 1-b]-1, 3, 4-thiadiazoles: a novel class of cyclooxygenase-2 …

…, K Anand, MN Noolvi, TS Boreddy, J Wagwade

文献索引：Gadad, Andanappa K.; Palkar, Mahesh B.; Anand; Noolvi, Malleshappa N.; Boreddy, Thippeswamy S.; Wagwade Bioorganic and Medicinal Chemistry, 2008 , vol. 16, # 1 p. 276 - 283

全文：HTML全文

被引用次数: 80

摘要

A series of 2-trifluoromethyl/sulfonamido-5, 6-diarylsubstituted imidazo [2, 1-b]-1, 3, 4- thiadiazole derivatives 15a–j have been synthesized by the reaction of 2-amino-5- trifluoromethyl/sulfonamido-1, 3, 4-thiadiazoles 14a–b and appropriately substituted α- bromo-1, 2-(p-substituted) diaryl-1-ethanones 13a–h. Structures of these compounds were established by IR, 1H NMR, 13C NMR, Mass, and HRMS data. The selected compounds ...