Aryl-Grignards (3+ equiv) react with 2, 6-dibromoiodobenzene or other 1, 2, 3- trihalobenzenes to give 2, 6-diarylphenylmagnesium halides. The mechanism involves Grignard exchange at the central halogen, followed by two cycles of magnesium halide loss and regioselective capture of the resulting aryne by the aryl-Grignard reagent (Scheme I). Typical examples are shown in Table I. The method is especially applicable to m- ...
![1,3,5-trimethyl-2-[3-(2,4,6-trimethylphenyl)phenyl]benzene结构式](https://image.chemsrc.com/caspic/381/103068-13-9.png)
