Spasmolytic Effects, Mode of Action, and Structure-Activity Relationships of Stilbenoids from Nidema boothii,⊥

Y Hernández-Romero, JI Rojas, R Castillo…

文献索引：Hernandez-Romero, Yanet; Rojas, Juana-Isela; Castillo, Rafael; Rojas, Alejandra; Mata, Rachel Journal of Natural Products, 2004 , vol. 67, # 2 p. 160 - 167

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被引用次数: 53

摘要

A CH2Cl2-MeOH (1: 1) extract prepared from the whole plant of Nidema boothii inhibited spontaneous contractions (IC50= 6.26±2.5 μg/mL) of the guinea-pig ileum. Bioassay-guided fractionation of the active extract led to the isolation of the novel spiro compound 1, which was given the trivial name nidemone, and the new dihydrophenanthrene 3, characterized as 1, 5, 7-trimethoxy-9, 10-dihydrophenanthrene-2, 6-diol. In addition, the known stilbenoids ...