Isotopic effect study of propofol deuteration on the metabolism, activity, and toxicity of the anesthetic

J Helfenbein, C Lartigue, E Noirault…

文献索引：Journal of Medicinal Chemistry, , vol. 45, # 26 p. 5806 - 5808

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被引用次数: 32

摘要

... Journal of Medicinal Chemistry. ... Indeed, it may induce some modifications of the chemical and physicochemical properties of the labeled drugs (polarity, molar volume, electron donation, van der Waals forces, dipolar moment, and lipophilicity) and therefore may contribute to ...