Tetrahedron

New synthesis of β-lactams

M Mori, K Chiba, M Okita, I Kayo, Y Ban

文献索引：Mori; Chiba; Okita; et al. Tetrahedron, 1985 , vol. 41, # 2 p. 375 - 385

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被引用次数: 66

摘要

α-Methylene-β-lactams 3 were synthesized from the various 2-bromoallylamine derivatives 2 using a catalytic amount of Pd (OAc) 2 or PD (acac) 2 and PPh3, under 1–4 atom pressure of CO in good yields. Similarly, α-alkylidene-β-lactams 20 were synthesized from 3-alkyl-2- bromoallylamines 19, which were easily prepared from the olefins 14, in the same manner.