Multicomponent reactions (MCRs) are synthetically highly efficient and economical as they offer high structural diversity and incorporate molecular units of all reaction components in a single step.[1] A well-known example of an MCR is the Mannich reaction, in which the educts formaldehyde, an amine, and a ketone or aldehyde are converted directly into the adduct bearing the molecular fragments of all components. It has been established as a ...
