Chirality

The Use of Phosphite??Type Ligands in the Ir??Catalyzed Asymmetric Hydrogenation of Heterocyclic Compounds

…, PY Ivanov, A Melman, VS Velezheva, VA Davankov

文献索引：Lyubimov, Sergey E.; Ozolin, Dmitry V.; Ivanov, Pavel Yu; Melman, Artem; Velezheva, Valeriya S.; Davankov, Vadim A. Chirality, 2014 , vol. 26, # 1 p. 56 - 60

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被引用次数: 4

摘要

ABSTRACT A series of chiral phosphite-type ligands was tested in asymmetric Ir-catalyzed hydrogenation of quinolines and 2, 4, 5, 6-tetrahydro-1H-pyrazino (3, 2, 1-j, k) carbazole. Hydrogenation of quinaldine hydrochloride provided superior enantioselectivity up to 65% ee compared to quinaldine free base. The ligands were tested for the first time in the asymmetric Ir-Ircatalyzed hydrogenation of 2, 4, 5, 6-tetrahydro-1H-pyrazino (3, 2, 1-j, k) ...