Synthesis, anti-inflammatory and analgesic activity of pyrido [2, 1-b] quinazoline derivatives

AI Mikhalev, ME Kon'shin, LA Ovodenko…

文献索引：Mikhalev, A. I.; Kon'shin, M. E.; Ovodenko, L. A.; Zaks, A. S. Pharmaceutical Chemistry Journal, 1995 , vol. 29, # 2 p. 124 - 126 Khimiko-Farmatsevticheskii Zhurnal, 1995 , vol. 29, # 2 p. 40 - 42

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被引用次数: 7

摘要

Among the structural analogs of pyridoquinazolines, compounds having a diverse biological activity have been dis- covered [1, 2]. We previously prepared derivatives of pyri- do[2, lb]quinazoline with pronounced anti-inflammatory and analgesic activity [3]. To continue these studies, and also to search for new drugs, we synthesized unknown derivatives of pyri- do[2,1-b]quinazole on the basis of 2-chloronicotinic acid, its nitrile and amides (Ia- h) [4] by reacting them with ...