Synthesis of phosphinic acid transition state analogues for the reaction catalysed by kynureninase

FC Ross, NP Botting, PD Leeson

文献索引：Ross, Fiona C.; Botting, Nigel P.; Leeson, Paul D. Bioorganic and Medicinal Chemistry Letters, 1996 , vol. 6, # 22 p. 2643 - 2646

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被引用次数: 12

摘要

... 4. NP Botting; ... mp188 °C (dec.); υ max (nujol)/cm −1 3320 (OH acid), 1690 (CO acid), 1225 (P=O, R 2 (OH)P=O); δ H (200MHz, 2 H 2 O) 2.5 (2H, m, -PCH 2− ), 3.6 (3H, d, POCH 3 , J PH 10Hz), 4.1 (1H, m, α-H), 7.35–7.80 (5H, m, Ph); δ C (74.76 MHz, 2 H 2 O) 29.63 (d, C-3, J PC 100Hz), 49.45 (s, C-2), 52.57 (d, POCH 3 , J PC 5.6Hz), 128.74 (d, ortho ... aromatic, J PC 169Hz), 172.27 (s, CO2H); δ P (121.49 MHz, 2 H 2 O) 47.94, 48.59; m/z (CI) 244 ([M+H] + , 100%). ...