Evaluation of secondary amide replacements in a series of CCR5 antagonists as a means to increase intrinsic membrane permeability. Part 1: Optimization of gem- …

…, J Wanner, A Jekle, G Heilek, C Ji, P Berry…

文献索引：Lemoine, Remy C.; Petersen, Ann C.; Setti, Lina; Wanner, Jutta; Jekle, Andreas; Heilek, Gabrielle; deRosier, Andre; Ji, Changhua; Berry, Pamela; Rotstein, David Bioorganic and Medicinal Chemistry Letters, 2010 , vol. 20, # 2 p. 704 - 708

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被引用次数: 13

摘要

Download PDF Opens in a new window. Article suggestions will be shown in a dialog on return to ScienceDirect. ... Please enable JavaScript to use all the features on this page. ... Replacement of a secondary amide with an N-acyl or N-sulfonyl gem-disubstituted azacyle in a series of CCR5 antagonists led to the identification of compounds with excellent in vitro HIV antiviral activity and increased intrinsic membrane permeability. ... Replacement of a secondary amide with ...