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Catalysis today

Mechanistic investigation of the one-pot formation of amides by oxidative coupling of alcohols with amines in methanol

J Mielby, A Riisager, P Fristrup, S Kegnæs

文献索引:Mielby, Jerrik; Riisager, Anders; Fristrup, Peter; Kegnaes, Soren Catalysis Today, 2013 , vol. 203, p. 211 - 216

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被引用次数: 11

摘要

The one-pot formation of amides by oxidative coupling of alcohols and amines via intermediate formation of methyl ester using supported gold and base as catalysts was studied using the Hammett methodology. Determining the relative reactivity of four different para-substituted benzyl alcohol derivatives showed that the first step of the reaction generates a partial positive charge in the benzylic position (ie by hydride abstraction), ...