Evaluation of [11 C] hemicholinium-15 and [18 F] hemicholinium-15 as new potential PET tracers for the high-affinity choline uptake system in the heart
…, JC Lopshire, JG Rosenberger, C Dusa, MK Das…
文献索引：Gao, Mingzhang; Miller, Michael A.; DeGrado, Timothy R.; Mock, Bruce H.; Lopshire, John C.; Rosenberger, Joshua G.; Dusa, Cristian; Das, Mithilesh Kumar; Groh, William J.; Zipes, Douglas P.; Hutchins, Gary D.; Zheng, Qi-Huang Bioorganic and Medicinal Chemistry, 2007 , vol. 15, # 3 p. 1289 - 1297
[11C] Hemicholinium-15 ([11C] HC-15) and [18F] hemicholinium-15 ([18F] HC-15) have been synthesized as new potential PET tracers for the heart high-affinity choline uptake (HACU) system.[11C] HC-15 was prepared by N-[11C] methylation of the appropriate precursor, 4-methyl-2-phenyl-morpholin-2-ol, using [11C] CH3OTf in 55–70% radiochemical yield decay corrected to end of bombardment (EOB) and 2–3Ci/μmol specific activity at ...
