Carbon substituted derivatives of the 1, 4-tetrahydrothiazine ring system (1)(thiomorpholine) have rarely been studied. N-Substituted derivatives have been prepared, 2 but the only carbon-substituted compound which has been reported is 2, 6-dimethylthiomorpholine. This paper is concerned with the synthesis of all nine possible C-methyl-l, 4-thiazans, prepared via the reaction of bis-2-haloethylamines with sodium sulfide (A) or bis-2-haloethyl ...
