Journal of the American Chemical Society

Anti-thyroid drugs and thyroid hormone synthesis: effect of methimazole derivatives on peroxidase-catalyzed reactions

G Roy, G Mugesh

文献索引：Roy, Gouriprasanna; Mugesh Journal of the American Chemical Society, 2005 , vol. 127, # 43 p. 15207 - 15217

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被引用次数: 95

摘要

Syntheses and characterization of the selenium analogue (MSeI) of anti-thyroid drug methimazole and a series of organoselenium compounds bearing N-methylimidazole pharmacophore are described. In contrast to the sulfur compound that exists predominantly in its thione form, the selenium analogue exists in a selenol form, which spontaneously oxidizes in air to produce the corresponding diselenide. The reduction of the diselenide by ...