Potent benzimidazolone based human β 3-adrenergic receptor agonists

…, A Kriauciunas, DP Matthews, T Miles, DA Neel…

文献索引：Finley, Don R.; Bell, Michael G.; Borel, Anthony G.; Bloomquist, William E.; Cohen, Marlene L.; Heiman, Mark. L.; Kriauciunas, Aidas; Matthews, Donald P.; Miles, Tania; Neel, David A.; Rito, Christopher J.; Sall, Daniel J.; Shuker, Anthony J.; Stephens, Thomas W.; Tinsley, Frank C.; Winter, Mark A.; Jesudason, Cynthia D. Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 21 p. 5691 - 5694

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被引用次数: 5

摘要

Download PDF Opens in a new window. Article suggestions will be shown in a dialog on return to ScienceDirect. ... Please enable JavaScript to use all the features on this page. ... The synthesis and biological evaluation of a series of benzimidazolone β 3 adrenergic receptor agonists are described. A trend toward the reduction of rat atrial tachycardia upon increasing steric bulk at the 3-position of the benzimidazolone moiety was observed.