Imidazo [1, 5-a] pyridines: a new class of thromboxane A2 synthetase inhibitors

…, T Campbell, C Gemenden, R Goldstein…

文献索引：Ford; Browne; Campbell; Gemenden; Goldstein; Gude; Wasley Journal of Medicinal Chemistry, 1985 , vol. 28, # 2 p. 164 - 170

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被引用次数: 65

摘要

Thromboxane A,(TxA,) is an extremely unstable natural product with potent vasoconstricting, bronchoconstricting, and platelet aggregating activities., It has been implicated in the etiology of a variety of disorders including vasospasm, stroke, ischemia, and myocardial infar~ tion.~ The biosynthesis of TxA2 from arachidonic acid is blocked by classical nonsteroidal antiinflammatory drugs which prevent the formation of its precursors ...