A mild, high-yielding procedure for the preparation of β-ketophosphonates is described. The condensation is general with respect to the ester and phosphonate, and the products are obtained in high yields within minutes at 0° C. The reaction procedure is operationally simple and amenable to large-scale preparations.
![Dimethyl [(2-indanoyl)methyl] phosphonate结构式](https://image.chemsrc.com/caspic/492/53273-26-0.png)