Spirocyclic β-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitors: From hit to lowering of cerebrospinal fluid (CSF) amyloid β in a higher species
…, JP Rizzi, K Regal, D Sammond…
文献索引：Ghosh, Arun K.; Venkateswara Rao, Kalapala; Yadav, Navnath D.; Anderson, David D.; Gavande, Navnath; Huang, Xiangping; Terzyan, Simon; Tang, Jordan Journal of Medicinal Chemistry, 2012 , vol. 55, # 21 p. 9195 - 9207,13 Title/Abstract Full Text Show Details Ghosh, Arun K.; Venkateswara Rao, Kalapala; Yadav, Navnath D.; Anderson, David D.; Gavande, Navnath; Huang, Xiangping; Terzyan, Simon; Tang, Jordan Journal of Medicinal Chemistry, 2012 , vol. 55, # 21 p. 9195 - 9207
A hallmark of Alzheimer's disease is the brain deposition of amyloid beta (Aβ), a peptide of 36–43 amino acids that is likely a primary driver of neurodegeneration. Aβ is produced by the sequential cleavage of APP by BACE1 and γ-secretase; therefore, inhibition of BACE1
