Biologically active heteroarotinoids exhibiting anticancer activity and decreased toxicity

…, JB Gale, MK Patterson, B Wang, W Wang…

文献索引：Benbrook, Doris M.; Madler, Matora M.; Spruce, Lyle W.; Birckbichler, Paul J.; Nelson, Eldon C.; Subramanian, Shankar; Mahika Weerasekare; Gale, Jonathan B.; Patterson Jr., Manford K.; Wang, Binghe; Wang, Wei; Lu, Shennan; Rowland, Tami C.; DiSivestro, Paul; Lindamood III, Charles; Hill, Donald L.; Berlin, K. Darrell Journal of Medicinal Chemistry, 1997 , vol. 40, # 22 p. 3567 - 3583

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被引用次数: 53

摘要

A series of retinoids, containing heteroatoms in a cyclic ring and called heteroarotinoids, were synthesized, and their biological activity was evaluated using tissue culture lines that have measurable responses to trans-retinoic acid (t-RA). Transglutaminase (TGase) was assessed in the human erythroleukemia cell line (GMO6141A) as an indicator of differentiation and apoptosis. Proliferation was evaluated in a human cervical cell line, CC ...