High threo diastereoselectivity via europium (III)-catalyzed cyclocondensation of a silyloxy diene with. alpha.-alkoxy aldehydes. Synthesis of (-) pestalotin

MM Midland, RS Graham

文献索引：Midland, M. Mark; Graham, Richard S. Journal of the American Chemical Society, 1984 , vol. 106, # 15 p. 4294 - 4296

全文：HTML全文

被引用次数: 74

摘要

Lewis acid catalyzed cyclocondensation of silyloxy dienes with dieneophiles has become a powerful method of constructing complex structures in a single step.'The cyclocondensation of the appropriately substituted diene with an aldehyde or ketone provides a potentially efficient and convergent method of synthesizing a variety of Since our research group is interested in the asymmetric synthesis of y-and M a~ tones,~ we chose to investigate the ...