Tetrahedron

Solid-phase combinatorial synthesis of benzothiazoles, benzimidazoles, and benzoxazoles using a traceless linker

H Hioki, K Matsushita, M Kubo, K Harada, M Kodama…

文献索引：Hioki, Hideaki; Matsushita, Kimihito; Kubo, Miwa; Harada, Kenichi; Kodama, Mitsuaki; Fukuyama, Yoshiyasu Tetrahedron, 2007 , vol. 63, # 46 p. 11315 - 11324

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被引用次数: 25

摘要

New methodology for the solid-phase synthesis of benzothiazoles, benzimidazoles, and benzoxazoles has been developed by using a traceless 4-alkoxy-aniline linker. The desired products were released from the polymer support by imine-exchange process coupled with air oxidation. Combinatorial library consisting of 36 members has been synthesized using this linker. The yields are low to good, which highly depend on the building blocks. ...