The stereochemical course and mechanism of the IspH reaction

…, NL Brock, P Rabe, JS Dickschat

文献索引：Citron, Christian A.; Brock, Nelson L.; Rabe, Patrick; Dickschat, Jeroen S. Angewandte Chemie - International Edition, 2012 , vol. 51, # 17 p. 4053 - 4057

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被引用次数: 20

摘要

Two pathways exist for the biosynthesis of the terpene monomers dimethylallyl diphosphate (DMAPP) and isopentenyl diphosphate (IPP): the mevalonate pathway [1] and the deoxyxylulose phosphate (DOX) pathway.[2, 3] Many pathogenic bacteria and the malaria parasite Plasmodium falciparum exclusively use the DOX pathway, which is essential in these organisms.[4, 5] Since this pathway is not present in humans, its enzymes represent ...