Abstract Condensation of 2-bromoacetophenones with sodium succinimide gave N- phenacylsuccinimides (1) which were opened with sodium hydroxide to N- phenacylsuccinamic acids (2). The latter were cyclized to 5-aryl-2-oxazolepropionic acids (3) in sulfuric acid. Similar cyclization of N-phenacylphthalamic acid (5) and succinic acid 2- benzoylhydrazide (7) gave o-(5-phenyl-2-oxazolyl) benzoic acid (6) and 5-phenyl-1, 3, 4- ...
![N-[2-(4-fluoro-phenyl)-2-oxo-ethyl]-succinamic acid结构式](https://image.chemsrc.com/caspic/407/24246-93-3.png)
![3-[5-(4-氟苯基)-1,3-噁唑]丙酸结构式](https://image.chemsrc.com/caspic/466/23464-94-0.png)