Studies on the synthetic and structural aspects of benzosuberones bearing 2, 4-thiazolidenone moiety as potential anti-cancer agents

…, R Bantu, CG Kumar, S Pombala, J Nanubolu

文献索引：Nagarapu, Lingaiah; Yadagiri, Bandi; Bantu, Rajashaker; Kumar, C. Ganesh; Pombala, Sujitha; Nanubolu, Jagadesh European Journal of Medicinal Chemistry, 2014 , vol. 71, p. 91 - 97

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被引用次数: 17

摘要

Abstract Novel representative of the important group of biologically active benzosuberones bearing 2, 4-thiazolidenone moiety was synthesized as potential anticancer agents (6a–j). These compounds were synthesized in good yields from Knoevenagel condensation of compounds 2a–b with thiazolidenone derivatives 3a–e in the presence of sodium acetate and glacial acetic acid. The in vitro cytotoxicity of these compounds was evaluated against ...