One-pot reaction of aromatic aldehydes, cyanothioacetamide and malononitrile under microwave irradiation proved to be an efficient way for the synthesis of 2,6-diamino-4-aryl-4H-thiopyran-3 ,5-dicarbonitriles without any added catalyst. ... Keywords: microwave heating, thioamides, malononitrile, 4H-thiopyrans, multi-component reactions ... Recently thiopyran derivatives have gained increasing attention due to their importance as key units in medicinal chemistry ...
