The Implications of (2S, 4S)??Hydroxyproline 4??O??Glycosylation for Prolyl Amide Isomerization

…, A Lee, K Marat, F Schweizer

文献索引：Owens, Neil W.; Lee, Adrian; Marat, Kirk; Schweizer, Frank Chemistry - A European Journal, 2009 , vol. 15, # 40 p. 10649 - 10657

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被引用次数: 12

摘要

Abstract The conformations of peptides and proteins are often influenced by glycans O- linked to serine (Ser) or threonine (Thr).(2S, 4R)-4-Hydroxyproline (Hyp), together with L- proline (Pro), are interesting targets for O-glycosylation because they have a unique influence on peptide and protein conformation. In previous work we found that glycosylation of Hyp does not affect the N-terminal amide trans/cis ratios (K trans/cis) or the rates of ...