Potent antimitotic and cell growth inhibitory properties of substituted chalcones

…, R Forrest, JA Hadfield, A Kendall, NJ Lawrence…

文献索引：Ducki, Sylvie; Forrest, Richard; Hadfield, John A.; Kendall, Alex; Lawrence, Nicholas J.; McGown, Alan T.; Rennison, David Bioorganic and Medicinal Chemistry Letters, 1998 , vol. 8, # 9 p. 1051 - 1056

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被引用次数: 348

摘要

A series of substituted chalcones was synthesised and screened for cytotoxic activity against the K562 human leukaemia cell line.(E)-3-(3 ″-Hydroxy-4 ″-methoxyphenyl)-2-methyl-1- (3′, 4′, 5′-trimethoxyphenyl)-prop-2-en-1-one [IC50 (K562) 0.21 nM] was found to be the most active. A relationship between the conformation and cytotoxicity of the chalcones is discussed.