Tetrahedron

Isolation, structural elucidation, and biosynthesis of 15-norlankamycin derivatives produced by a type-II thioesterase disruptant of Streptomyces rochei

K Arakawa, Z Cao, N Suzuki, H Kinashi

文献索引：Arakawa, Kenji; Cao, Zhisheng; Suzuki, Natsumi; Kinashi, Haruyasu Tetrahedron, 2011 , vol. 67, # 29 p. 5199 - 5205

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被引用次数: 3

摘要

Abstract Lankamycin, a 14-membered macrolide antibiotic, contains a 3-hydroxy-2-butyl side chain at C-13. To analyze the function of lkmE, which encodes type-II thioesterase in the lankamycin cluster, we carried out a gene disruption experiment. Disruption of lkmE resulted in a 70% decrease of lankamycin production concomitant with an accumulation of novel lankamycin derivatives (LM-NS01A and LM-NS01B), in which the C-13 side chain is ...