Resolved monophenolic 2-aminotetralins and 1, 2, 3, 4, 4a, 5, 6, 10b-octahydrobenzo [f] quinolines: structural and stereochemical considerations for centrally acting …

H Wikstroem, B Andersson, D Sanchez…

文献索引：Wikstroem, Hakan; Andersson, Bengt; Sanchez, Domingo; Lindberg, Per; Arvidsson, Lars-Erik; et al. Journal of Medicinal Chemistry, 1985 , vol. 28, # 2 p. 215 - 225

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被引用次数: 79

摘要

A detailed structure-activity relationship is revealed for resolved, centrally acting dopamine (DA) agonists acting on both pre-and postsynaptic DA receptors. The compounds resolved are 5-and 7-hydroxy-2-(di-n-propylamino) tetralin and cis-and trans-7-hydroxy-4-n-propyl-1, 2, 3, 4, 4a, 5, 6, l0b-octahydrobenzo~ quinoline. By the superimposition of the structures of the more active enantiomers of these compounds with those of known dopaminergic ...