Design and biological evaluation of phenyl-substituted analogs of β-phenylethylidenehydrazine

B Sowa, G Rauw, A Davood, A Fassihi…

文献索引：Sowa, Bernard; Rauw, Gillian; Davood, Asghar; Fassihi, Afshin; Knaus, Edward E.; Baker, Glen B. Bioorganic and Medicinal Chemistry, 2005 , vol. 13, # 14 p. 4389 - 4395

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被引用次数: 9

摘要

β-Phenylethylidenehydrazine (PEH) has been demonstrated previously to be an inhibitor of γ-aminobutyric acid transaminase (GABA-T) and to cause a marked increase in rat brain levels of GABA, a major neurotransmitter. A group of PEH analogs, possessing a variety of substituents (Me, OMe, Cl, F, and CF3) at the 2-, 3-, and 4-positions of the phenyl ring, were synthesized for evaluation as inhibitors of GABA-T. The details of the synthesis and ...