Structure− Activity Relationships of Substituted 1-Pyridyl-2-phenyl-1, 2-ethanediones: Potent, Selective Carboxylesterase Inhibitors

BM Young, JL Hyatt, DC Bouck, T Chen…

文献索引：Journal of Medicinal Chemistry, , vol. 53, # 24 p. 8709 - 8715

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被引用次数: 8

摘要

... Journal of Medicinal Chemistry. ... enzymes believed to be responsible for hydrolysis of xenobiotics in the body by catalyzing the hydrolysis of esters to the corresponding alcohols and carboxylic acids.(1) Since it is known that a number of important pharmaceutical agents are ...