Efficient palladium??catalyzed coupling of aryl chlorides and tosylates with terminal alkynes: Use of a copper cocatalyst inhibits the reaction

D Gelman, SL Buchwald

文献索引：Gelman, Dmitri; Buchwald, Stephen L. Angewandte Chemie - International Edition, 2003 , vol. 42, # 48 p. 5993 - 5996

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被引用次数: 316

摘要

Aryl alkynes are important intermediates in organic synthesis.[1] Currently, palladium and copper cocatalyzed alkyne synthesis, the Sonogashira reaction, is the most straightforward and powerful method for the construction of C (sp2)–C (sp) bonds. The original protocol [2] has been repeatedly modified and improved to overcome several significant limitations: a) the use of various palladacycles led to catalytic systems with higher turnover numbers,[3] ...