The First Enantioselective Approach to 13a??Methyl??14??hydroxyphenanthroindolizidine Alkaloids–Synthetic Studies towards Hypoestestatin 2

B Su, M Deng, Q Wang

文献索引：Su, Bo; Deng, Meng; Wang, Qingmin European Journal of Organic Chemistry, 2013 , # 10 p. 1979 - 1985

全文：HTML全文

被引用次数: 2

摘要

Abstract The first enantioselective approach to 13a-methyl-14- hydroxyphenanthroindolizidine alkaloids was achieved in six linear steps from phenanthryl alcohol and features a highly substrate-dependent Parham cycloacylation and Seebach's enantioselective alkylation as the key steps. The route is concise, protecting-group free, provides access to all stereoisomers, and works on a gram scale. In addition to the ...