Microanalysis of a selective potent anti-Helicobacter pylori compound in a Brazilian medicinal plant, Myroxylon peruiferum and the activity of analogues

…, J Takashima, N Chiba, M Kawamura

文献索引：Ohsaki, Ayumi; Takashima, Junko; Chiba, Noriko; Kawamura, Makoto Bioorganic and Medicinal Chemistry Letters, 1999 , vol. 9, # 8 p. 1109 - 1112

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被引用次数: 55

摘要

A selective potent anti-Helicobacter pylori isoflavone was isolated from a Brazilian Medicinal Plant, Myroxylon peruiferum. The isolation bioassay-guided and the characterization of an active anti-H. pylori constituent was performed using the methanol extract of plant of minute amount. The active compound was identified as cabreuvin (1), an isoflavone derivative. The structure-activity relationships of several related compounds were also investigated.