1, 4-Benzodiazepines as inhibitors of respiratory syncytial virus. The identification of a clinical candidate

…, J Budworth, MC Carter, A Chubb…

文献索引：Henderson, Elisa A.; Alber, Dagmar G.; Baxter, Robert C.; Bithell, Sian K.; Budworth, Joanna; Carter, Malcolm C.; Chubb, Ann; Cockerill, G. Stuart; Dowdell, Verity C. L.; Fraser, Ian J.; Harris, Robert A.; Keegan, Sally J.; Kelsey, Richard D.; Lumley, James A.; Stables, Jeremy N.; Weerasekera, Natasha; Wilson, Lara J.; Powell, Kenneth L. Journal of Medicinal Chemistry, 2007 , vol. 50, # 7 p. 1685 - 1692

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被引用次数: 41

摘要

Respiratory syncytial virus (RSV) is the cause of one-fifth of all lower respiratory tract infections worldwide and is increasingly being recognized as representing a serious threat to patient groups with poorly functioning or immature immune systems. Racemic 1, 4- benzodiazepines show potent anti-RSV activity in vitro. Anti-RSV evaluation of 3-position R- and S-benzodiazepine enantiomers and subsequent optimization of this series resulted in ...