Organic & biomolecular chemistry

Investigation of the origin and synthetic application of the pseudodilution effect for Pd-catalyzed macrocyclisations in concentrated solutions with immobilized catalysts

E Brehm, R Breinbauer

文献索引：Brehm, Elisabeth; Breinbauer, Rolf Organic and Biomolecular Chemistry, 2013 , vol. 11, # 29 p. 4750 - 4756

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被引用次数: 6

摘要

Immobilized Pd-complexes allowed macrocyclisations via the Tsuji–Trost-reaction in concentrated solutions. Systematic studies suggest that the origin of this pseudodilution effect is neither film diffusion nor gel diffusion, but the reduction in conformational freedom of intermediates and intramolecular prenucleophile activation. In contrast a pseudodilution effect could not be observed for Sonogashira-and Suzuki-macrocyclisations.