Structural optimization of enantiopure 2-cyclialkylamino-2-aryl-1, 1-diphenylethanols as catalytic ligands for enantioselective additions to aldehydes

…, L Sola, A Vidal-Ferran, MA Pericas

文献索引：Garcia-Delgado, Noemi; Reddy, Katamreddy Subba; Sola, Lluis; Riera, Antoni; Pericas, Miquel A.; Verdaguer, Xavier Journal of Organic Chemistry, 2005 , vol. 70, # 18 p. 7426 - 7428

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被引用次数: 37

摘要

The structural optimization of a family of modular, enantiopure β-amino alcohol ligands with a common 2-amino-2-aryl-1, 1-diphenylethanol skeleton, whose stereogenicity was introduced through the Jacobsen epoxidation of 1, 1-diphenyl-2-arylethylenes, has led to the identification of a small set of optimal catalysts with enhanced activity and enantioselectivity in the addition of alkylzinc and arylzinc reagents to aldehydes. Criteria for the ...