Novel 1H-(benzimidazol-2-yl)-1H-pyridin-2-one inhibitors of insulin-like growth factor I (IGF-1R) kinase

MD Wittman, B Balasubramanian, K Stoffan…

文献索引：Bioorganic and Medicinal Chemistry Letters, , vol. 17, # 4 p. 974 - 977

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被引用次数: 23

摘要

... Bioorganic & Medicinal Chemistry Letters. ... Using chemistry originally described by Curran 11a and Fang 11b in the course of their campothecin work, the 4-iodopyridone (7) was prepared according to Scheme 1. Starting from the commercially available 5-fluoro-2-nitro-toluene ...