Novel coordinating motifs for lanthanide (III) ions based on 5-(2-pyridyl) tetrazole and 5-(2-pyridyl-1-oxide) tetrazole. Potential new contrast agents

…, S Bradamante, P Mariani, CL Stern, TJ Marks…

文献索引：Facchetti, Antonio; Abbotto, Alessandro; Beverina, Luca; Bradamante, Silvia; Mariani, Palma; Stern, Charlotte L.; Marks, Tobin J.; Vacca, Alberto; Pagani, Giorgio A. Chemical Communications, 2004 , # 15 p. 1770 - 1771

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被引用次数: 11

摘要

From this intense research effort, all heteroaromatic-based ligands are practically absent. This is surprising considering the rich chemistry, stability, and good coordinating properties of many heterocycles. 5 We describe here a new family of ligands (LH = 1–4) based on the pyridine/pyridine-N-oxide–tetrazole skeleton. Ligands 3 and 4 bearing hydrophilic chains were envisioned to improve solubility in water. Thanks to the acidity of tetrazole (pK a = 4.89 in ...