NHC-catalyzed generation of difluorocarbene and its application to difluoromethylation of oxygen nucleophiles

…, Y Koseki, T Aono, H Sasagawa, J Ichikawa

文献索引：Fuchibe, Kohei; Koseki, Yuta; Aono, Tatsuya; Sasagawa, Hisashi; Ichikawa, Junji Journal of Fluorine Chemistry, 2012 , vol. 133, p. 52 - 60

全文：HTML全文

被引用次数: 19

摘要

Controlled generation of difluorocarbene was effected by an NHC catalyst under mild conditions starting from trimethylsilyl 2, 2-difluoro-2-fluorosulfonylacetate (TFDA). Cyclohexenones and tetralones were treated with TFDA in the presence of catalytic amounts of N, N′-dimesitylimidazolium chloride and sodium carbonate. The ketones were difluoromethylated with the generated difluorocarbene to afford enol difluoromethyl ethers ...