Tetrahedron: Asymmetry

Synthesis of novel nitrogen-containing ligands for the enantioselective addition of diethylzinc to aldehydes

MH Fonseca, E Eibler, M Zabel, B König

文献索引：Fonseca, Maria Hechavarria; Eibler, Ernst; Zabel, Manfred; Koenig, Burkhard Tetrahedron Asymmetry, 2003 , vol. 14, # 14 p. 1989 - 1994

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被引用次数: 34

摘要

New nitrogen-containing ligands derived from the (1R, 2R)-trans-cyclohexanediamine chiral core unit have been synthesized and fully characterized. Their catalytic activity was tested in the asymmetric addition of diethylzinc to aldehydes leading to the respective secondary alcohols with enantioselectivities of up to 74% ee.